Maity, hansda, bandyopadhyay, mishra, 2009, biological activities of crude extracts and chemical constituents of bael, aegle marmelos l. Dgalactopyranoside isolated from the stem bark of aegle marmelos correa. Antidiabetic and antihyperlipidemic activities of the leaf. Repon kumer saha, arfatoon nesa, kamrun nahar and mahfuja akter. After getting the sample fruit as dried powder, some sample was used for lactin isolation by ammonium sulphate precipitation method and some were used for methanolic extraction. Protective effect and mechanism of fruit extract of aegle. Rutaceae, commonly known as bael in nepal and india, is a valuable medicinal plant and is considered sacred by the hindus. Aegle marmelos plant the deciduous leaves originates singly orin 2s 3s are of 3 5 oval leaflets, 4 10 cm. India is predicted to have the largest number of people with diabetes mellitus 4. Pdf antidiabetic activity of aegle marmelos and its relationship. Aegle marmelos, callus culture, methanolic extraction, antidiabetic activity introduction aegle marmelos l. Invitro antidiabetic and antimicrobial activity of silver. The rats of either sex were randomly divided in to 7 groups 6 rats group and were fasted overnight 18hrs.
Evaluation of antiobesity effect of aegle marmelos leaves. Leaves of aegle marmelos flowers are greenish white in color and have bisexual, actinomorphic, hypogynous. It is found as a wild plant in central and south india and cultivated in north india. In the present study, an attempt has been made to investigate clinically the antidiabetic activity of bael leaves bl aegle marmelos, corr. In vivo antidiabetic activity a marked rise in fasting blood glucose levels were observed in diabetic group when compared with normal control rats. Recent trends in medicinal uses and health benefits of indian. Phytochemical analysis on leaf extract of aegle marmelos. Phytochemical profile and pharmacological activity of. Rutaceae, commonly known as bael, is used to treat fevers, abdomen pain. Oct 20, 20 the object of the present study was to evaluate the antidiabetic, antihyperlipidemic and antioxidant oxidative stress of umbelliferone.
Marmelosin was separated out from extraction of aegle marmelos. Introduction all over the world, diabetes mellitus is increasing. Antidiabetic activity of leaf extracts of aegle marmelos linn in streptozotocin nicotinamide induced diabetic wistar albino rats. S hort report antidiabetic activity of leaf and callus extracts of aegle marmelos in rabbit sevugan arumugama, subramanian kavimanib, balamuthu kadalmanic, abdul bakrudeen ali ahmedd, mohammed abdulkadar akbarshac, mandali venkateswara raod, a national taiwan university, taipei 106, taiwan. Oxidative stress induced by alloxan has been shown to damage pancreatic. Aegle marmelos is a subtropical, usually medium to bigsized deciduous tree growing well in dry forests of plain and hilly area up to a height of about 1200 m above sea level and can adapt to a. When the body cannot produce sufficient amount of insulin the blood glucose level increases. Antidiabetic activities of the fruit aegle mamelos abstract. Beneficial effects of aegle marmelos leaves on induced.
Nutritional aspects of aegle marmelos bael aegle marmelos is one of the most valuable indian medicinal plants. The study revealed that the in vitro callus culture of a. The inadequacies, as well as serious adverse effects associated with conventional medicines, led to a determined search for alternative natural therapeutic agents. D i a b e tes o f t l a n r u o siol journal of diabetes and. Till date no study has been reported on the antioxidant activity of. The present study was performed to evaluate the hyperglycemic effect of aqueous extract of a. Antidiabetic activity of partitionates of aegle marmelos linn.
Phytochemical analysis on leaf extract of aegle marmelos correa. Aegle marmelos leaf extract is being used in ayurveda as a medicine for diabetes. Antidiabetic and antioxidant activity of aegle marmelos extract in streptozotocininduced diabetic rats. Evaluation of antidiabetic and antioxidant activity of aegle.
Introduction diabetes mellitus is the one of the challenging health problem in twentyfirst century that is occurring throughout the world today. Antidiabetic activity of standardized dried tubers extract of. Characterization of phytochemicals, minerals and in vitro. Diabetes has become a common disease around the world. Invitro studies on antidiabetic effect of aegle marmelos plant. The present study has been undertaken to evaluate the antidiabetic activity of marmelosin extracted from aegle marmelos. Clinical evaluation of antidiabetic activity of trigonella.
The object of the present study was to evaluate the antidiabetic, antihyperlipidemic and antioxidant oxidative stress of umbelliferone. Department of pharmacy, higher college of technology, p. Total phenols content tpc, total flavonoid contents tfc and antioxidant activity were determined by folinciocalteu reagent method, aluminium chloride colorimetric technique and 2, 2diphenyl l picrylhydrazyl dpph scavenging assay respectively. Evaluation of antidiabetic activity in alloxan induced diabetic wistar rats fed with the various extracts of r. The present study examined the action of aegle marmelos against experimental. According to the recent findings 14, 15, substances with cytotoxic activities are therapeutically recommended for antidiabetic activity. Marmelosin was separated out from extraction of aegle marmelos by column chromatography methods. Aegle marmelos also displayed antioxidative effect in in vivo as it enhanced resistance to. Most of the observed biological activity was apparently due to the relatively high level of limonene 64. The aim of the present study was to determine the antidiabetic activity of the hydroalcoholic extracts of bark of anacardium occidentale, whole aerial part of achyranthes aspera and leaf of aegle marmelos. Phytochemical evaluation, antimicrobial activity, and. Antidiabetic activity of leaf and callus extracts of aegle. Pdf aegle marmelos the bael tree is a popular medicinal plant in the ayurveda and siddha systems of medicine and folk medicines used to treat. Aegle marmelos the bael tree is a popular medicinal plant in the ayurveda and siddha systems of medicine and folk medicines used to treat.
To the best of the authors knowledge, there are no previous scientific reports on the antidiabetic activity of the leaf latex of a. Bael fruit, stone apple or aegle marmelos and its health. Extraction and isolation of marmelosin from aegle marmelos. The aim of the present study was to investigate presence of antidiabetic activity in plant extracts like syzyium cumini, aegle marmelos and cocos nucifera using a solvent like methanol and aqueous. After getting the sample fruit as dried powder, some sample was used for lactin isolation by ammonium sulphate precipitation method and some were. Correa, and to explore the ethnoconservation strategies for its long term sustainability. It grows well in the dry forests of hilly and plain areas.
Evaluation of antidiabetic and antioxidant activity of. Diabetes was induced in rat by single intraperitoneal injection of stz 60 mgkg. Aegle marmelos, alloxan, antidiabetic, hyperglycemia. Aegle marmelos leaf extract is a one of the best ayurveda medicine for diabetes mellitus. Antidiabetic activity medicinal plant aegle marmelos international. Antidiabetic activity of hydroalcoholic extracts of anacardium occidentale, aegle marmelos and achyranthes aspera in alloxaninduced diabetic rats brijyog 1, 2, laliteshwar pratap singh 1, sushil kumar 2 and shweta verma 2 institute of pharmacy 1, harish chandra p. Pdf antidiabetic activity of leaf and callus extracts of. Antidiabetic activity of aegle marmelos and its relationship with its antioxidant properties february 2004 indian journal of physiology and pharmacology 481. The leaf latex extract of aloe megalacantha has been used for the management of diabetes mellitus in ethiopian folk medicine. It is present in india, sri lanka, nepal, thailand, and malesia as a naturalized species. Tremendous pharmacological values of aegle marmelos. Fruit is rich source of mineral, vitamin and fibre. Phytochemical analysis on leaf extract of aegle marmelos correa sonu singh, neeta singh abstract aegle marmelos is a subtropical plant which can grow up to an altitude of 1200 m from the sea level. Aegle marmelos, antibacterial, anticancer, antidiabetic, antifungal, antihyperlipidaemic, antioxidant.
Antidiabetic activity medicinal plant aegle marmelos. Antidiabetic activity of rephanus sativus l, leaves. Biological activities of crude extracts and chemical. Minerals and antibacterial activity introduction the wood apple aegle marmelos or popularly known as bael tree in bengali is native to the indomalayan region 1 and is currently. Dgalactopyranoside ufg from stem bark of aegle marmelos correa. Pdf clinical evaluation of antidiabetic activity of. Pdf evaluation of antidiabetic and antioxidant activity of aegle. Antidiabetic and antioxidant activity of aegle marmelos extract in. Aegle marmelos, commonly known as bael or bili or bhel, also bengal quince, golden apple, japanese bitter orange, stone apple or wood apple, is a species of tree native to the indian subcontinent and southeast asia. Antidiabetic activity of aegle marmelos and its relationship with its antioxidant properties. Citeseerx clinical evaluation of antidiabetic activity. Ashrafuzzaman sapon, monokesh kumer sen abstract in the last few years, there has been an exponential growth in the field of herbal medicine and gaining.
The results of this work provided the referential information for the identification and standardization of aconitum napellus along with its role as a hypoglycemic agent. Phytochemical profile and pharmacological activity of aegle. The extraction of plant material in different solvent like petroleum ether, chloroform and ethanol by soxhelation was carried out. Evaluation of antidiabetic and antioxidant activity of aegle marmelos l. Pdf antidiabetic activity of aegle marmelos and its. Various proved therapeutic values of aegle marmelos are antidiabetic activity, hepatoprotective activity, antimicrobial activity, analgesic activity, antiinflammatory, antipyretic activity and anticancer activity etc. Antidiabetic activity of rephanus sativus l, leaves extracts. Pdf aegle marmelos antidiabetic activity bakrudeen. Oral, as well as intraperitoneal administrations of the aqueous extract of bael fruit exhibited hypoglycemic effect against streptozotocin induced diabetic rats, the fruit extract at a dose of 250 mgkg exhibited good results kamalakkanan et al. The methanol extract of leaves of aegle marmelos at a dose level of 200 and 300 mgkg showed significant analgesic activity on acetic acidinduced writhing and tail flick test in mice. Biological activities and volatile constituents of aegle. Antidiabetic activity of leaf extracts of aegle marmelos. The objective of this study is pharmacological activities investigation of aegle marmelos fruit. Aqueous extract of aegle marmelos leaves, was evaluated for.
Invitro studies on antidiabetic effect of aegle marmelos. Jan 22, 2020 the results of antidiabetic activity showed that the plant can be used as a potent source for the treatment of diabetes and its complications. Venugopalan1 1agroprocessing and natural products division, csirniist, thiruvananthapuram, kerala. Chemical studies prove that bael fruit is rich in nutritional value, and this is being used from several years ago.
Invitro antidiabetic activity was through alphaamylase analyzed inhibitory test, the silver nanoparticle exhibited 100gml maximum inhibitory effect on the enzyme in a dependentdose manner. Aegle marmelos, antilipid peroxidation, aqueous extract, catalase. Extract in regulation of antidiabetic activity ruchi r. Aegle marmelos is a plant that belongs to a family of rutaceae. A number of methods were employed for this investigation, including dpph 1, 1diphenyl2picrylhydrazyl radical scavenging. The oil and dry fruit powder is an important export commodity from india giving a handsome amount of foreign. Diabetes mellitus has become a major public health and economic problem across the globe. Pdf antidiabetic activity of leaf and callus extracts of aegle. Rutaceae, commonly known as bael, is used to treat fevers, abdomen pain, palpitation of the heart, urinary troubles, melancholia, anorexia, dyspepsia, diabetes and diarrhea in indian traditional systems of medicine. Aegle marmelos, diabetes mellitus, alloxan, blood glucose level, body weight. Antihyperglycemic activity of alcoholic leaf extract of. Aegle marmelos commonly known as bilwa or bael,is highly valued plant for its characteristic aroma and medicinal value. Invitro antidiabetic and antimicrobial activity of.
Marmelos a plant of indian origin, with phytopharmacological properties has shown to reduce metabolic disorder such as cholesterol level and blood sugar levels. Since in the previous research 11 it was established that umbelliferone is a potent free radical scavenger and works as antioxidant. In the present study, an attempt has been made to investigate clinically the antidiabetic activity of fenugreek seeds fg trigonella foenumgraceum linn. Recent trends in medicinal uses and health benefits of. Shamim hossain, naim hassan, biplab kumar dash, md. It is used to cure several diseases in the indian traditional medicine system of ayurveda and has had similar uses among many ethnic communities residing in indian subcontinent for over 5000 years.
Ethanolic extract of rumex vesicarius at 100, 200, 400 mgkg exhibited a dose dependent significant antidiabectic activity. Vacuum liquid chromatography vlc, thin layer chromatography tlc were used to detect the presence of various types of compound in rind. Activity and hyperglycemic effect of aqueous extract of a. D i a b e tes o f t l a n r u o siol journal of diabetes. Pdf clinical evaluation of antidiabetic activity of bael. Pdf aegle marmelos antidiabetic activity bakrudeen ali.
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